Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM233023
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
33±n/a nM
Citation
 Bag, S; Tawari, NR; Queener, SF; Degani, MS Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms. J Enzyme Inhib Med Chem 25:331-9 (2010) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM233023
Synonyms:
2-(4-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)butyl)isoindoline-1,3-dione (A2-03)
Type:
Small organic molecule
Emp. Form.:
C23H26N6O3
Mol. Mass.:
434.4909
SMILES:
CC1(C)N=C(N)N=C(N)N1c1ccc(OCCCCN2C(=O)c3ccccc3C2=O)cc1 |t:3,6|
Structure:
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