Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM233044
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.45e+4±n/a nM
Citation
 Badarau, E; Putey, A; Suzenet, F; Joseph, B; Bojarski, A; Finaru, A; Guillaumet, G New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation. J Enzyme Inhib Med Chem 25:301-5 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM233044
Synonyms:
2-(2-Pyrrolo[2,3-b]pyridin-1-ylethyl)decahydropyrido[1,2-a][1,4]diazepine (5)
Type:
Small organic molecule
Emp. Form.:
C18H26N4
Mol. Mass.:
298.4258
SMILES:
C(Cn1ccc2cccnc12)N1CCCN2CCCCC2C1
Structure:
Search PDB for entries with ligand similarity: