Reaction Details Report a problem with these data
Target
Ras-like protein 2
Ligand
BDBM233117
Substrate
n/a
Meas. Tech.
Fluorescence-Based PFTase Inhibition Assay
pH
7.5±0
Temperature
303.15±0 K
IC50
>1.000e+6±n/a nM
Citation
 Pinel, B; Dubois, J; Séraphin, D; Richomme, P Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase. J Enzyme Inhib Med Chem 25:172-9 (2010) [PubMed]  Article 
Target
Name:
Ras-like protein 2
Synonyms:
ASC1 | CTN5 | GLC5 | Protein farnesyltransferase (PFTase) | RAS2 | RAS2_YEAST
Type:
Enzyme
Mol. Mass.:
34705.81
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P01120
Residue:
322
Sequence:
MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS
  
Inhibitor
Name:
BDBM233117
Synonyms:
α-Methylene-γ-lactone, 3
Type:
Small organic molecule
Emp. Form.:
C17H24O5
Mol. Mass.:
308.3695
SMILES:
CC(O)CC(OC(C)=O)C1=CC[C@H]2[C@H](C[C@@H]1C)OC(=O)C2=C |r,t:9|
Structure:
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