Reaction Details Report a problem with these data
Target
Polyphenol oxidase 1
Ligand
BDBM50198715
Substrate
n/a
Meas. Tech.
In Vitro Tyrosinase Inhibition Assay
pH
6.8±n/a
Temperature
298.15±n/a K
IC50
3.68e+3± 2e+1 nM
Comments
extracted
Citation
 Khan, SB; Hassan Khan, MT; Jang, ES; Akhtar, K; Seo, J; Han, H Tyrosinase inhibitory effect of benzoic acid derivatives and their structure-activity relationships. J Enzyme Inhib Med Chem 25:812-7 (2010) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM50198715
Synonyms:
(2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid | CHEMBL245416 | L-mimosine
Type:
Small organic molecule
Emp. Form.:
C8H10N2O4
Mol. Mass.:
198.176
SMILES:
N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: