Reaction Details Report a problem with these data
Target
Enteropeptidase
Ligand
BDBM234240
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Ki
0.56±n/a nM
Comments
extracted
Citation
 Suzuki, T; Koshiba, T; Tokumasu, M; Ohsumi, K Heterocyclic carboxylic acid ester derivative US Patent  US9346821 Publication Date 5/24/2016 
Target
Name:
Enteropeptidase
Synonyms:
ENTK | ENTK_HUMAN | PRSS7 | TMPRSS15
Type:
Enzyme
Mol. Mass.:
112901.62
Organism:
Homo sapiens (Human)
Description:
P98073
Residue:
1019
Sequence:
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
  
Inhibitor
Name:
BDBM234240
Synonyms:
US9346821, A-14
Type:
Small organic molecule
Emp. Form.:
C23H28N4O8
Mol. Mass.:
488.4904
SMILES:
CC(C)[C@H](N(C)Cc1ccc(o1)C(=O)Oc1ccc(cc1)C(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Structure:
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