Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM234207
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
>205000±n/a nM
Comments
extracted
Citation
 Lin, H; He, B Methods of treatment using modulators of SIRT2 US Patent  US9359293 Publication Date 6/7/2016 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM234207
Synonyms:
US9359293, TH
Type:
Small organic molecule
Emp. Form.:
C26H35N3O3S
Mol. Mass.:
469.639
SMILES:
CCCCCCC(=S)NCCCCC(NC(=O)Oc1ccccc1)C(=O)Nc1ccccc1
Structure:
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