Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [645-1186]
Ligand
BDBM234327
Substrate
n/a
Meas. Tech.
EGFR Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
50000±n/a nM
Comments
extracted
Citation
 Zhu, ZW; Shi, L; Ruan, XM; Yang, Y; Li, HQ; Xu, SP; Zhu, HL Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase. J Enzyme Inhib Med Chem 26:37-45 (2011) [PubMed]  Article 
Target
Name:
Epidermal growth factor receptor [645-1186]
Synonyms:
EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1
Type:
Protein
Mol. Mass.:
60974.10
Organism:
Homo sapiens (Human)
Description:
Human EGFR cytoplasmic domain (645-1186 aa)
Residue:
542
Sequence:
SIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGI
  
Inhibitor
Name:
BDBM234327
Synonyms:
3,5-Dibromo-N-(4-fluorophenyl)-2-hydroxybenzamide (29)
Type:
Small organic molecule
Emp. Form.:
C13H8Br2FNO2
Mol. Mass.:
389.015
SMILES:
Oc1c(Br)cc(Br)cc1C(=O)Nc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: