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Target
Polyphenol oxidase 1
Ligand
BDBM50234650
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
pH
6.8±0
Temperature
298.15±0 K
IC50
1.05e+4±n/a nM
Citation
 Wu, J; Hu, X; Ma, L Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors. J Enzyme Inhib Med Chem 26:449-52 (2011) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM50234650
Synonyms:
2,3,4-trihydroxybenzophenone | CHEMBL1527 | Polyhydroxy benzophenone, 17 | hsp90_149 | phenyl(2,3,4-trihydroxyphenyl)methanone
Type:
Small organic molecule
Emp. Form.:
C13H10O4
Mol. Mass.:
230.2161
SMILES:
Oc1ccc(C(=O)c2ccccc2)c(O)c1O
Structure:
Search PDB for entries with ligand similarity: