Reaction Details Report a problem with these data
Target
UDP-glucuronosyltransferase 1A4
Ligand
BDBM50121975
Substrate
Midazolam
Meas. Tech.
UDP-glucuronosyltransferase Activity Assay
IC50
1.66e+5± 1.8e+4 nM
Citation
 Liu, Y; She, M; Wu, Z; Dai, R The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors. J Enzyme Inhib Med Chem 26:386-93 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A4
Synonyms:
Bilirubin-specific UDPGT isozyme 2 | GNT1 | GNT1 | UD14_HUMAN | UDP-glucuronosyltransferase 1-4 | UDP-glucuronosyltransferase 1-D | UDP-glucuronosyltransferase 1A4 | UDPGT 1-4 | UGT-1D | UGT1 | UGT1*4 | UGT1-04 | UGT1.4 | UGT1A4 | UGT1D | Uridine-5'-diphosphoglucuronosyltransferase 1A4 | hUG-BR2
Type:
Enzyme
Mol. Mass.:
60042.50
Organism:
Homo sapiens (Human)
Description:
P22310
Residue:
534
Sequence:
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50121975
Synonyms:
(6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol | CARDIOQUIN | CHEMBL1294 | CIN-QUIN | DURAQUIN | QUINACT | QUINAGLUTE | QUINALAN | QUINATIME | QUINIDEX | QUINIDINE | QUINORA | US9402878, Quinidine
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2
Mol. Mass.:
324.4168
SMILES:
COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |r,THB:20:19:12.13:16.15,10:12:18.19:16.15|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21363
Synonyms:
12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine | CHEMBL655 | Dormicum | Midazolam | Ro 21-3981 | US20230416258, Compound Midazolam
Type:
Small organic molecule
Emp. Form.:
C18H13ClFN3
Mol. Mass.:
325.767
SMILES:
Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 |t:6|
Structure:
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