Reaction Details
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Plasmepsin IV [1-448]
Ligand
BDBM234527
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
4.5±n/a
Temperature
298.15±n/a K
IC50
10±n/a nM
Comments
extracted
Citation
Chen, X; Ding, K; Meyers, MJ; Tortorella, MD; Xu, J Compositions and methods for the treatment of malaria US Patent US9353089 Publication Date 5/31/2016 More Info.:
Target
Name:
Plasmepsin IV [1-448]
Synonyms:
PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV)
Type:
Enzyme
Mol. Mass.:
50925.00
Organism:
Plasmodium falciparum
Description:
Q8IM16[1-448]
Residue:
448
Sequence:
MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGNFYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYLGSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFILGDPFMRKYFTVFDYEKESVGFAVAKN
Inhibitor
Name:
BDBM234527
Synonyms:
US9353089, 206
Type:
Small organic molecule
Emp. Form.:
C27H34N4O5
Mol. Mass.:
494.5827
SMILES:
COc1ccc(cc1)C1(NC(=N)N(C2CCN(CC2)C(=O)OC(C)(C)C)C1=O)c1ccc(OC)cc1
Structure:
