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Target
Calcium/calmodulin-dependent protein kinase type II subunit delta
Ligand
BDBM292455
Substrate
n/a
Meas. Tech.
CaMKII delta Biochemical Assay
IC50
0.050±n/a nM
Citation
 Elzein, E; Kalla, RV; Koltun, D; Li, X; Parkhill, EQ; Perry, T; Simonovich, SP; Zablocki, J; Ziebenhaus, CA Fused heterocyclic compounds as CaM kinase inhibitors US Patent  US10100058 Publication Date 10/16/2018 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56419.78
Organism:
Homo sapiens (Human)
Description:
Q13557
Residue:
499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Inhibitor
Name:
BDBM292455
Synonyms:
(R)-(2-(aminomethyl)piperidin-1-yl)(2-chloro-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-4-yl)methanone | US10100058, Example 111
Type:
Small organic molecule
Emp. Form.:
C22H21ClN6OS
Mol. Mass.:
452.96
SMILES:
NC[C@H]1CCCCN1C(=O)c1cc(Cl)nc(c1)-c1cnn2ccc(nc12)-c1cccs1 |r|
Structure:
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