Reaction Details
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Proto-oncogene tyrosine-protein kinase Src [251-533,T338C]
Ligand
BDBM234860
Substrate
n/a
Meas. Tech.
In vitro Kinase Assay
pH
8±n/a
IC50
1004±n/a nM
Comments
extracted
Citation
Garske, AL; Shokat, KM Methods and compositions for kinase inhibition US Patent US9353116 Publication Date 5/31/2016 More Info.:
Target
Name:
Proto-oncogene tyrosine-protein kinase Src [251-533,T338C]
Synonyms:
Proto-oncogene tyrosine-protein kinase Src (T338C) | SRC | SRC_CHICK
Type:
Protein
Mol. Mass.:
32362.46
Organism:
Gallus gallus (Chicken)
Description:
residues 251-533
Residue:
283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVCEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Inhibitor
Name:
BDBM234860
Synonyms:
US9353116, 19 | US9353116, Fig. 16, Compound 1
Type:
Small organic molecule
Emp. Form.:
C18H18N4O4S
Mol. Mass.:
386.425
SMILES:
COc1cc2ncnc(Nc3cccc(NS(=O)(=O)C=C)c3)c2cc1OC
Structure:
