Reaction Details Report a problem with these data
Target
Cytochrome P450 2D6
Ligand
BDBM7841
Substrate
n/a
Meas. Tech.
CYP Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
13200±n/a nM
Comments
extracted
Citation
 Pradhan, NS; Patil, NS; Walavalkar, RR; Kulkarni, NS; Pawar, SB; Pawar, TS Aldehyde derivative of substitute oxazolidinones US Patent  US9359341 Publication Date 6/7/2016 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM7841
Synonyms:
BAY 59-7939 Analog 18 | US8822458, 45 | US9359341, Rivaroxaban
Type:
n/a
Emp. Form.:
C20H21N3O5S
Mol. Mass.:
415.463
SMILES:
Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O |r|
Structure:
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