Reaction Details Report a problem with these data
Target
Epidermal growth factor receptor [668-1210]
Ligand
BDBM50123162
Substrate
n/a
Meas. Tech.
Luminescence Kinase Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
1.7±0.0 nM
Comments
extracted
Citation
 Zhang, D Quinazoline derivatives as kinases inhibitors and methods of use thereof US Patent  US9388160 Publication Date 7/12/2016 
Target
Name:
Epidermal growth factor receptor [668-1210]
Synonyms:
EGF-R Tyrosine Kinase | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase ErbB-1
Type:
Cytoplasmic region
Mol. Mass.:
61304.06
Organism:
Homo sapiens (Human)
Description:
Wildtype EGFR was purchased from Invitrogen.
Residue:
543
Sequence:
MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM50123162
Synonyms:
CHEMBL3622673 | US9388160, 11
Type:
Small organic molecule
Emp. Form.:
C27H29N5O2
Mol. Mass.:
455.5515
SMILES:
CCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1NC(=O)\C=C\CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: