Reaction Details Report a problem with these data
Target
Glutathione reductase, mitochondrial
Ligand
BDBM50056998
Substrate
n/a
Meas. Tech.
Activity Assay
pH
8±0
Temperature
298.15±0 K
Ki
6.1e+3± 1.27e+3 nM
IC50
2.9e+4±n/a nM
Citation
 Karaman, M; Akkemik, E; Budak, H; Ciftci, M In vitro effects of some drugs on human erythrocyte glutathione reductase. J Enzyme Inhib Med Chem 27:18-23 (2012) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50056998
Synonyms:
4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid (5-methyl-thiazol-2-yl)-amide | 4-Hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid (5-methyl-thiazol-2-yl)-amide | CHEMBL599 | MELOXICAM | Meloxicam sodium | Mobic | UH-AC 62XX | UHAC-62XX
Type:
Small organic molecule
Emp. Form.:
C14H13N3O4S2
Mol. Mass.:
351.401
SMILES:
CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O |t:12|
Structure:
Search PDB for entries with ligand similarity: