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Target
Aurora kinase B
Ligand
BDBM236509
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
31±n/a nM
Comments
extracted
Citation
 Xi, N; Li, M; Li, X; Dai, W; Wang, T Substituted heteroaryl compounds and methods of use US Patent  US9394281 Publication Date 7/19/2016 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM236509
Synonyms:
US9394281, 8
Type:
Small organic molecule
Emp. Form.:
C15H20ClN7O4S
Mol. Mass.:
429.882
SMILES:
Cn1cc(Nc2ncc(Cl)c(NC3COC4C(COC34)NS(C)(=O)=O)n2)cn1
Structure:
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