Reaction Details Report a problem with these data
Target
Carbonic anhydrase 6
Ligand
BDBM81195
Substrate
n/a
Meas. Tech.
CA Activity Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
1.15e+3±n/a nM
Citation
 Sentürk, M; Ekinci, D; Göksu, S; Supuran, CT Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI. J Enzyme Inhib Med Chem 27:365-9 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM81195
Synonyms:
(+/-)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide | 2-aminotetralin-6,7-diol;hydrobromide | 6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol | 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide | 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide | ADTN | ADTN, (+) | CA inhibitor, 3 | CHEMBL26736 | MLS002172466 | SMR001254097 | cid_11957526 | cid_3153
Type:
Small organic molecule
Emp. Form.:
C10H13NO2
Mol. Mass.:
179.2157
SMILES:
NC1CCc2cc(O)c(O)cc2C1
Structure:
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