Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM236786
Substrate
n/a
Meas. Tech.
In Vitro Affinity Assay
Temperature
310.15±n/a K
IC50
384±n/a nM
Comments
extracted
Citation
 Musicki, B; Aubert, J; Boiteaux, J; Clary, L; Rossio, P; Schuppli-Nollet, M Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases US Patent  US9388149 Publication Date 7/12/2016 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM236786
Synonyms:
US9388149, 17
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4S
Mol. Mass.:
401.479
SMILES:
CN1C=CC=C(Nc2c(NC(C3CCCS3)c3ccc(C)o3)c(=O)c2=O)C1O |w:10.10,c:2,t:4|
Structure:
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