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Target
Fructose-bisphosphate aldolase
Ligand
BDBM32144
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
79000±10000 nM
Citation
 Pegan, SD; Ahrendt, K; Capodagli, GC; Cowen, B Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase US Patent  US9394254 Publication Date 7/19/2016 
Target
Name:
Fructose-bisphosphate aldolase
Synonyms:
ALF_MYCTU | FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-1,6-bisphosphate aldolase (FBA) | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba | fba
Type:
Protein
Mol. Mass.:
36539.01
Organism:
Mycobacterium tuberculosis (strain H37Rv)
Description:
P9WQA3
Residue:
344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
  
Inhibitor
Name:
BDBM32144
Synonyms:
8-quinolinamine | 8-quinolylamine | AS-232 | US10005735, Table 1.2 | US9394254, 18 | cid_11359 | quinolin-8-amine
Type:
Small organic molecule
Emp. Form.:
C9H8N2
Mol. Mass.:
144.1732
SMILES:
Nc1cccc2cccnc12
Structure:
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