Reaction Details Report a problem with these data
Target
ETS domain-containing protein Elk-1
Ligand
BDBM237222
Substrate
n/a
Meas. Tech.
Cell-Based Enzyme Inhibition Assay (ELISA)
IC50
2.42e+3±n/a nM
Citation
 Li, QS; Lv, PC; Li, HQ; Lu, X; Li, ZL; Ruan, BF; Zhu, HL Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents. J Enzyme Inhib Med Chem 27:708-14 (2012) [PubMed]  Article 
Target
Name:
ETS domain-containing protein Elk-1
Synonyms:
ELK1 | ELK1_HUMAN | ETS domain-containing protein (Elk1)
Type:
Enzyme
Mol. Mass.:
44888.95
Organism:
Homo sapiens (Human)
Description:
P19419; phosphorylated
Residue:
428
Sequence:
MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSTMPNVAPAAIHAAPGDTVSGKPGTPKGAGMAGPGGLARSSRNEYMRSGLYSTFTIQSLQPQPPPHPRPAVVLPSAAPAGAAAPPSGSRSTSPSPLEACLEAEEAGLPLQVILTPPEAPNLKSEELNVEPGLGRALPPEVKVEGPKEELEVAGERGFVPETTKAEPEVPPQEGVPARLPAVVMDTAGQAGGHAASSPEISQPQKGRKPRDLELPLSPSLLGGPGPERTPGSGSGSGLQAPGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
  
Inhibitor
Name:
BDBM237222
Synonyms:
1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-3-phenylthiourea (3b)
Type:
Small organic molecule
Emp. Form.:
C22H22N2O3S
Mol. Mass.:
394.487
SMILES:
COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Structure:
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