Reaction Details Report a problem with these data
Target
Carbonic anhydrase 1
Ligand
BDBM45795
Substrate
n/a
Meas. Tech.
Esterase Activity Assay
IC50
322000±n/a nM
Citation
 Alp, C; Özsoy, Å¿; Alp, NA; Erdem, D; Gültekin, MS; Küfrevioglu, ÿİ; Sentürk, M; Supuran, CT Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI. J Enzyme Inhib Med Chem 27:818-24 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM45795
Synonyms:
4-methyl-N-(2-naphthalenyl)benzenesulfonamide | 4-methyl-N-(2-naphthyl)benzenesulfonamide | 4-methyl-N-naphthalen-2-yl-benzenesulfonamide | 4-methyl-N-naphthalen-2-ylbenzenesulfonamide | CA inhibitor, 3 | MLS-0090805.0001 | cid_224144
Type:
Small organic molecule
Emp. Form.:
C17H15NO2S
Mol. Mass.:
297.371
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: