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Target
Carbonic anhydrase 1
Ligand
BDBM50166571
Substrate
n/a
Meas. Tech.
Esterase Activity Assay
IC50
26190±n/a nM
Citation
 Alp, C; Özsoy, Å¿; Alp, NA; Erdem, D; Gültekin, MS; Küfrevioglu, ÿİ; Sentürk, M; Supuran, CT Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI. J Enzyme Inhib Med Chem 27:818-24 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM50166571
Synonyms:
2-sulfanilamidopyrimidine | 2-sulfanilylaminopyrimidine | 4-Amino-N-(pyridin-2-yl) benzenesulfonamide (Sulfapyridine) (13) | 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide | 4-amino-N-2-pyrimidinylbenzenesulfonamide | CHEMBL439 | N(1)-2-pyrimidinylsulfanilamide | N(1)-2-pyrimidylsulfanilamide | SULFADIAZINE | sulfapyrimidine | sulphadiazine
Type:
Small organic molecule
Emp. Form.:
C10H10N4O2S
Mol. Mass.:
250.277
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Structure:
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