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Target
Carbonic anhydrase 2
Ligand
BDBM39340
Substrate
n/a
Meas. Tech.
Esterase Activity Assay
IC50
276±n/a nM
Citation
 Alp, C; Özsoy, Å¿; Alp, NA; Erdem, D; Gültekin, MS; Küfrevioglu, ÿİ; Sentürk, M; Supuran, CT Sulfapyridine-like benzenesulfonamide derivatives as inhibitors of carbonic anhydrase isoenzymes I, II and VI. J Enzyme Inhib Med Chem 27:818-24 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM39340
Synonyms:
4-Amino-N-(pyrimidin-2-yl) benzenesulfonamide (Sulfadiazine) (14) | MLS000069725 | SMR000058213 | SULFAPYRIDINE | cid_5336
Type:
Small organic molecule
Emp. Form.:
C11H11N3O2S
Mol. Mass.:
249.289
SMILES:
Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Structure:
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