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Target
Histamine H1 receptor
Ligand
BDBM293413
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
271±n/a nM
Comments
extracted
Citation
 Rodes Solanes, R; Olivera Tizne, R; Hernández Herrero, G; Rubio Royo, V; Ledo Gómez, F Benzimidazole derivatives as antihistamine agents US Patent  US10106522 Publication Date 10/23/2018 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM293413
Synonyms:
US10106522, Compound I-3 in CN 103896915
Type:
Small organic molecule
Emp. Form.:
C30H33N3O4
Mol. Mass.:
499.6007
SMILES:
OC(=O)Cc1ccc(OCCN2CCC(CC2)c2nc3ccccc3n2CCOc2ccccc2)cc1
Structure:
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