Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM237363
Substrate
n/a
Meas. Tech.
CA Enzyme Assay
pH
10±n/a
IC50
3.412e+4±n/a nM
Comments
extracted
Citation
 Karatas, MO; Alici, B; Cakir, U; Cetinkaya, E; Demir, D; Ergün, A; Gençer, N; Arslan, O Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives. J Enzyme Inhib Med Chem 28:299-304 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM237363
Synonyms:
1-(2,3,5,6-Tetramethylbenzyl)-3-(4-methyl-7,8-dihydroxy-2H-chromen-2-one)benzimidazolium chloride (3h)
Type:
Small organic molecule
Emp. Form.:
C28H28N2O4
Mol. Mass.:
456.5329
SMILES:
Cc1cc(C)c(C)c(CN2CN(Cc3cc(=O)oc4c(O)c(O)ccc34)c3ccccc23)c1C
Structure:
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