Reaction Details Report a problem with these data
Target
Bromodomain testis-specific protein [1-397]
Ligand
BDBM237471
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
IC50
14±n/a nM
Comments
extracted
Citation
 Ren, B; Zhou, C; Wang, H Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones US Patent  US9393232 Publication Date 7/19/2016 
Target
Name:
Bromodomain testis-specific protein [1-397]
Synonyms:
BRDT | BRDT_HUMAN | Bromodomain testis-specific protein (BRDT)
Type:
Enzyme
Mol. Mass.:
45307.77
Organism:
Homo sapiens (Human)
Description:
aa 1-397
Residue:
397
Sequence:
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETT
  
Inhibitor
Name:
BDBM237471
Synonyms:
US9393232, 2.46
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2
Mol. Mass.:
402.4888
SMILES:
Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC[C@H](N)C3)(c2c1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: