Reaction Details Report a problem with these data
Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM238233
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Competition Immunoassay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.72±n/a nM
Comments
extracted
Citation
 Illig, CR; Ballentine, SK; Chen, J; Desjarlais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of c-fms kinase US Patent  US9403804 Publication Date 8/2/2016 
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CSF1R_MOUSE | Csf1r | Csfmr | Fms | Macrophage colony-stimulating factor 1 receptor | Macrophage colony-stimulating factor 1 receptor (c-Fms) | Proto-oncogene c-Fms
Type:
Protein
Mol. Mass.:
109173.45
Organism:
Mus musculus (Mouse)
Description:
P09581
Residue:
977
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFC
  
Inhibitor
Name:
BDBM238233
Synonyms:
US9403804, 44
Type:
Small organic molecule
Emp. Form.:
C29H37N5O3
Mol. Mass.:
503.6358
SMILES:
CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@]1(O)CC[C@@H](CC1)N1CCOCC1 |r,wU:24.27,28.34,wD:24.26,c:5,(-1.39,-2.42,;-2.16,-3.76,;-2.93,-2.42,;-.82,-4.53,;-.82,-6.07,;-2.16,-6.84,;-3.49,-6.07,;-3.49,-4.53,;-2.16,-8.38,;-3.49,-9.15,;-3.49,-10.69,;-2.16,-11.46,;-.82,-10.69,;-.82,-9.15,;.51,-8.38,;1.85,-9.15,;1.85,-10.69,;3.18,-8.38,;4.64,-8.85,;5.59,-7.61,;4.64,-6.36,;3.18,-6.84,;7.13,-7.61,;8.67,-7.61,;-4.82,-11.46,;-5.22,-9.97,;-6.31,-11.86,;-6.71,-13.34,;-5.62,-14.43,;-4.13,-14.03,;-3.73,-12.55,;-6.02,-15.92,;-7.51,-16.32,;-7.9,-17.81,;-6.82,-18.9,;-5.33,-18.5,;-4.93,-17.01,)|
Structure:
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