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Target
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]
Ligand
BDBM238903
Substrate
n/a
Meas. Tech.
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
IC50
120±n/a nM
Comments
extracted
Citation
 Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Vaupel, A Substituted purinone compounds US Patent  US9403827 Publication Date 8/2/2016 
Target
Name:
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
p53-MDM2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cellular tumor antigen p53 [18-26]
Synonyms:
P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:
Protein
Mol. Mass.:
1122.31
Organism:
Homo sapiens (Human)
Description:
aa 18-26
Residue:
9
Sequence:
TFSDLWKLL
  
Component 2
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN
Type:
Protein
Mol. Mass.:
21187.98
Organism:
Homo sapiens (Human)
Description:
aa 2-188
Residue:
187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
  
Inhibitor
Name:
BDBM238903
Synonyms:
US9403827, 5
Type:
Small organic molecule
Emp. Form.:
C20H16BrCl2FN4O
Mol. Mass.:
498.176
SMILES:
CC(C)N1C2C(N(C(=O)N=C2N=C1Br)c1cccc(Cl)c1F)c1ccc(Cl)cc1 |c:9,12|
Structure:
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