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Target
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Ligand
BDBM238900
Substrate
n/a
Meas. Tech.
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
IC50
2130±n/a nM
Comments
extracted
Citation
 Furet, P; Guagnano, V; Holzer, P; Kallen, J; Mah, R; Masuya, K; Schlapbach, A; Vaupel, A Substituted purinone compounds US Patent  US9403827 Publication Date 8/2/2016 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]/Protein Mdm4 [2-185]
Synonyms:
p53-MDM4
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
E3 ubiquitin-protein ligase Mdm2 [2-188]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN
Type:
Protein
Mol. Mass.:
21187.98
Organism:
Homo sapiens (Human)
Description:
aa 2-188
Residue:
187
Sequence:
CNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDS
  
Component 2
Name:
Protein Mdm4 [2-185]
Synonyms:
E3 ubiquitin-protein ligase Mdm4 | MDM4 | MDM4_HUMAN | MDMX | p53-binding protein Mdm4
Type:
Protein
Mol. Mass.:
20438.64
Organism:
Homo sapiens (Human)
Description:
aa 2-185
Residue:
184
Sequence:
TSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSR
  
Inhibitor
Name:
BDBM238900
Synonyms:
US9403827, 2
Type:
Small organic molecule
Emp. Form.:
C28H25Cl2FN4O2
Mol. Mass.:
539.428
SMILES:
COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
Structure:
Search PDB for entries with ligand similarity: