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Target
Isoform Beta-II of Protein kinase C beta type (PRKCB2)
Ligand
BDBM239072
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
EC50
6±n/a nM
Comments
extracted
Citation
 Baran, PS; Felding, J; Jin, Y; Yeh, C 3-O-acyl-ingenol analogues US Patent  US9409931 Publication Date 8/9/2016 
Target
Name:
Isoform Beta-II of Protein kinase C beta type (PRKCB2)
Synonyms:
KPCB_HUMAN | PKCB | PRKCB | PRKCB1 | Protein kinase C beta II type | Protein kinase C beta type (PRKCB2)
Type:
Enzyme
Mol. Mass.:
77017.33
Organism:
Homo sapiens (Human)
Description:
P05771-2
Residue:
673
Sequence:
MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS
  
Inhibitor
Name:
BDBM239072
Synonyms:
US9409931, 5
Type:
Small organic molecule
Emp. Form.:
C28H40O4
Mol. Mass.:
440.6148
SMILES:
C[C@@H]1C[C@@H]2[C@H]([C@@H]3C=C(CO)C[C@@H]4[C@@H](OC(=O)C5(C)CCCCC5)C(C)=C[C@@]14C3=O)C2(C)C |r,c:25,t:6|
Structure:
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