Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239892
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
1.28±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239892
Synonyms:
US9403767, 50 | US9403767, 51
Type:
Small organic molecule
Emp. Form.:
C28H34N2
Mol. Mass.:
398.583
SMILES:
CN(C)C1(CCC(CC1)(N(C)Cc1ccccc1)c1ccccc1)c1ccccc1 |(4.21,-3.03,;2.67,-3.08,;2.77,-1.54,;1.94,-4.44,;.61,-5.21,;.61,-6.75,;1.94,-7.52,;3.28,-6.75,;3.28,-5.21,;2.67,-8.88,;2.77,-10.42,;4.21,-8.93,;4.93,-10.29,;6.47,-10.35,;7.19,-11.71,;6.38,-13.01,;4.84,-12.96,;4.11,-11.6,;1.22,-8.88,;2.04,-10.19,;1.31,-11.55,;-.22,-11.6,;-1.04,-10.29,;-.32,-8.93,;1.22,-3.08,;-.32,-3.03,;-1.04,-1.67,;-.22,-.36,;1.31,-.41,;2.04,-1.77,)|
Structure:
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