Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM239894
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
10±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239894
Synonyms:
US9403767, 52
Type:
Small organic molecule
Emp. Form.:
C35H38N2O
Mol. Mass.:
502.689
SMILES:
CN(C)C1(CCC(CC1)(N(C)C(=O)C(c1ccccc1)c1ccccc1)c1ccccc1)c1ccccc1 |(-13.9,3.85,;-13.9,2.31,;-15.43,2.47,;-12.56,1.54,;-11.84,.18,;-10.3,.13,;-9.49,1.43,;-10.21,2.79,;-11.75,2.85,;-8.15,.66,;-6.62,.5,;-8.15,-.88,;-9.49,-1.65,;-6.82,-1.65,;-6.82,-3.19,;-5.48,-3.96,;-5.48,-5.5,;-6.82,-6.27,;-8.15,-5.5,;-8.15,-3.96,;-5.48,-.88,;-5.48,.66,;-4.15,1.43,;-2.82,.66,;-2.82,-.88,;-4.15,-1.65,;-8.1,2.11,;-7.99,3.64,;-6.61,4.32,;-5.33,3.46,;-5.44,1.92,;-6.82,1.25,;-13.95,.87,;-14.06,-.67,;-15.44,-1.35,;-16.72,-.48,;-16.61,1.05,;-15.22,1.73,)|
Structure:
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