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Target
Nociceptin receptor
Ligand
BDBM239918
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
15±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239918
Synonyms:
US9403767, 92 | US9403767, 93
Type:
Small organic molecule
Emp. Form.:
C26H32N4O
Mol. Mass.:
416.5585
SMILES:
CN(C)C1(CCC(CC1)(N(C)C(=O)c1ccn(C)n1)c1ccccc1)c1ccccc1 |(6.92,4.5,;8.39,4.02,;9.53,5.05,;8.71,2.51,;9.53,1.21,;8.8,-.15,;7.26,-.21,;6.45,1.1,;7.17,2.46,;7.26,-1.75,;6.64,-3.15,;8.6,-2.52,;9.93,-1.75,;8.6,-4.06,;7.35,-4.96,;7.83,-6.43,;9.37,-6.43,;10.27,-7.67,;9.84,-4.96,;5.99,-1.07,;6.09,-2.6,;4.82,-3.46,;3.43,-2.79,;3.33,-1.25,;4.6,-.39,;10.14,3.09,;10.35,4.62,;11.78,5.19,;12.99,4.24,;12.78,2.72,;11.35,2.14,)|
Structure:
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