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Target
Nociceptin receptor
Ligand
BDBM239923
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
2.45±n/a nM
Comments
extracted
Citation
 Nolte, B; Schröder, W; Linz, K; Englberger, W; Schick, H; Graubaum, H; Braun, B; Ozegowski, S; Bálint, J; Sonnenschein, H Substituted 4-aminocyclohexane derivatives US Patent  US9403767 Publication Date 8/2/2016 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM239923
Synonyms:
US9403767, 101 | US9403767, 102
Type:
Small organic molecule
Emp. Form.:
C26H34N4
Mol. Mass.:
402.575
SMILES:
CN(C)C1(CCC(CC1)(N(C)Cc1ccn(C)n1)c1ccccc1)c1ccccc1 |(-.13,-15.77,;.49,-14.36,;1.83,-15.13,;-.41,-13.12,;-.52,-11.58,;-1.91,-10.91,;-3.18,-11.77,;-3.07,-13.3,;-1.69,-13.98,;-4.09,-10.52,;-5.42,-9.75,;-3.46,-9.11,;-4.37,-7.87,;-5.91,-7.87,;-6.38,-6.4,;-5.14,-5.5,;-5.14,-3.96,;-3.89,-6.4,;-4.72,-11.82,;-5.44,-13.18,;-6.98,-13.23,;-7.8,-11.93,;-7.08,-10.57,;-5.54,-10.52,;1.13,-13.06,;1.85,-11.7,;3.39,-11.65,;4.2,-12.96,;3.48,-14.32,;1.94,-14.37,)|
Structure:
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