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Target
Orexin receptor type 2
Ligand
BDBM240193
Substrate
n/a
Meas. Tech.
Intracellular Calcium Assay
Temperature
310.15±n/a K
IC50
1±n/a nM
Comments
extracted
Citation
 Bolli, M; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Azetidine amide derivatives as orexin receptor antagonists US Patent  US9403813 Publication Date 8/2/2016 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM240193
Synonyms:
US9403813, 98
Type:
Small organic molecule
Emp. Form.:
C22H20ClN7O4
Mol. Mass.:
481.892
SMILES:
CCOc1ncccc1-c1nc(no1)[C@@H]1CCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1
Structure:
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