Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM240745
Substrate
n/a
Meas. Tech.
Cell Based Assay
pH
7.4±n/a
Temperature
310.15±n/a K
EC50
100±n/a nM
Comments
extracted
Citation
 Martos, JL; Carling, WR; Woodward, DF; Wang, JW; Kangasmetsa, JJ Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response US Patent  US9422273 Publication Date 8/23/2016 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM240745
Synonyms:
US9422273, 12c
Type:
Small organic molecule
Emp. Form.:
C30H41F3N4O6S
Mol. Mass.:
642.73
SMILES:
COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1 |r|
Structure:
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