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Target
Genome polyprotein [1973-2419]
Ligand
BDBM241831
Substrate
n/a
Meas. Tech.
Luciferase Assay
EC50
0.072±n/a nM
Citation
 Zhang, J; Zhang, Y; Xie, H; Ren, Q; Hu, B; Fu, C; Wu, X; Li, S; Wang, C; Zhang, Z Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof US Patent  US9416139 Publication Date 8/16/2016 
Target
Name:
Genome polyprotein [1973-2419]
Synonyms:
Non-structural protein 5A (NS5A) | POLG_HCVCO | RNA-directed RNA polymerase (NS5B)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48705.67
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
Q9WMX2[1973-2419]
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFLVGLNQYLVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFEPLQAEEDEREVSVPAEILRRSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLSESTVSSALAELATKTFGSSESSAVDSGTATASPDQPSDDGDAGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCC
  
Inhibitor
Name:
BDBM241831
Synonyms:
US9416139, 9
Type:
Small organic molecule
Emp. Form.:
C53H62F2N8O7
Mol. Mass.:
961.1056
SMILES:
COC(=O)N[C@@H](C(C)C)C(=O)N1C[C@@H](F)C[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(c2CC3(Cc12)CCCCC3)-c1ccc2nc([nH]c(=O)c2c1)[C@@H]1C[C@H](F)CN1C(=O)[C@@H](NC(=O)OC)C(C)C |r|
Structure:
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