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Target
Sphingosine kinase 1
Ligand
BDBM241906
Substrate
n/a
Meas. Tech.
Kinase Assay
Temperature
310.15±n/a K
Ki
200±n/a nM
Comments
extracted
Citation
 Lynch, KR; Macdonald, TL; Mathews, TP; Kennedy, A; Kharel, Y Imidamide sphingosine kinase inhibitors US Patent  US9421177 Publication Date 8/23/2016 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM241906
Synonyms:
US9421177, VPC96047
Type:
Small organic molecule
Emp. Form.:
C23H37N3O2
Mol. Mass.:
387.5588
SMILES:
CCCCCCCCCCCCc1ccc(cc1)C(=O)NC1(CC1)C(\N)=N\O
Structure:
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