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Target
Genome polyprotein [1027-1207,R155K]
Ligand
BDBM241940
Substrate
n/a
Meas. Tech.
FRET Assay
pH
7.5±n/a
IC50
>3000±n/a nM
Comments
extracted
Citation
 Niu, D; Petter, RC; Qiao, L; Singh, J HCV protease inhibitors and uses thereof US Patent  US9422333 Publication Date 8/23/2016 
Target
Name:
Genome polyprotein [1027-1207,R155K]
Synonyms:
POLG_HCV1 | Protease NS3/Non-structural protein 4A (NS3/NS4A) (R155K)
Type:
Enzyme
Mol. Mass.:
19093.28
Organism:
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
Description:
P26664[1027-1207,R155K]
Residue:
181
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFKAAVCTRGVAKAVDFIPVENLETTMRS
  
Inhibitor
Name:
BDBM241940
Synonyms:
US9422333, I-1
Type:
Small organic molecule
Emp. Form.:
C27H42N6O6
Mol. Mass.:
546.659
SMILES:
CC(C)(C)NC(=O)N[C@@H](CNC(=O)C=C)C(=O)N1CC2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C |r,w:25.26|
Structure:
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