Reaction Details Report a problem with these data
Target
Interstitial collagenase [100-268]
Ligand
BDBM50066659
Substrate
n/a
Meas. Tech.
cd-MMP-1 Activity Assay
pH
7.5±n/a
IC50
13±n/a nM
Comments
extracted
Citation
 Lu, W; Zhu, J; Zou, S; Li, X; Huang, J The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem 28:741-6 (2013) [PubMed]  Article 
Target
Name:
Interstitial collagenase [100-268]
Synonyms:
CLG | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 (cd-MMP-1)
Type:
Enzyme
Mol. Mass.:
18886.85
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human MMP-1 (100-268 aa)
Residue:
169
Sequence:
FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQ
  
Inhibitor
Name:
BDBM50066659
Synonyms:
1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-HEXAHYDRO-PYRIMIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE | CHEMBL115727 | MMP inhibitor II
Type:
Small organic molecule
Emp. Form.:
C21H27N3O8S2
Mol. Mass.:
513.584
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CC(C)(C)CN(C1C(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Structure:
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