Reaction Details Report a problem with these data
Target
Interstitial collagenase [100-268]
Ligand
BDBM50386892
Substrate
n/a
Meas. Tech.
cd-MMP-1 Activity Assay
pH
7.5±n/a
IC50
10±n/a nM
Comments
extracted
Citation
 Lu, W; Zhu, J; Zou, S; Li, X; Huang, J The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors. J Enzyme Inhib Med Chem 28:741-6 (2013) [PubMed]  Article 
Target
Name:
Interstitial collagenase [100-268]
Synonyms:
CLG | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 (cd-MMP-1)
Type:
Enzyme
Mol. Mass.:
18886.85
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human MMP-1 (100-268 aa)
Residue:
169
Sequence:
FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQ
  
Inhibitor
Name:
BDBM50386892
Synonyms:
CHEMBL2048512 | MMP inhibitor III
Type:
Small organic molecule
Emp. Form.:
C19H29N3O4
Mol. Mass.:
363.4513
SMILES:
CNC(=O)C(CCc1ccccc1)NC(=O)C(CC(C)C)CC(=O)NO
Structure:
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