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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242353
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
13±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242353
Synonyms:
US10047093, 8-9 | US10392392, Example 8-9 | US10875864, EX. 8-9 | US9416132, 8-9
Type:
Small organic molecule
Emp. Form.:
C20H21F3N4O2
Mol. Mass.:
406.4015
SMILES:
C[C@]1(O)CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:1.1,wD:5.8,1.0,(-7.91,3.91,;-7.14,2.57,;-8.68,2.57,;-5.8,3.34,;-4.47,2.57,;-4.47,1.03,;-5.8,.26,;-7.14,1.03,;-3.14,.26,;-1.8,1.03,;-1.8,2.57,;-.47,3.34,;.86,2.57,;2.33,3.05,;3.23,1.8,;2.33,.56,;2.73,-.93,;1.64,-2.02,;2.04,-3.51,;3.52,-3.91,;4.67,-2.83,;6.15,-3.23,;7.24,-2.14,;8.33,-1.05,;8.33,-3.23,;6.15,-1.05,;4.22,-1.33,;.86,1.03,;-.47,.26,)|
Structure:
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