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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242372
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
5±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242372
Synonyms:
US10047093, 8-29 | US10392392, Example 8-29 | US10875864, EX. 8-29 | US9416132, 8-29
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O
Mol. Mass.:
376.3756
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:4.7,wD:1.0,(-8.03,4.02,;-6.7,3.25,;-6.7,1.71,;-5.36,.94,;-4.03,1.71,;-4.03,3.25,;-5.36,4.02,;-2.7,.94,;-1.36,1.71,;-1.36,3.25,;-.03,4.02,;1.31,3.25,;2.77,3.73,;3.68,2.48,;2.77,1.24,;3.17,-.25,;2.08,-1.34,;2.48,-2.83,;3.97,-3.23,;5.15,-2.13,;4.66,-.65,;6.64,-2.51,;8.14,-2.89,;6.26,-4,;7.03,-1.02,;1.31,1.71,;-.03,.94,)|
Structure:
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