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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242374
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
1±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242374
Synonyms:
US10047093, 8-31 | US10392392, Example 8-31 | US10875864, EX. 8-31 | US9416132, 8-31
Type:
Small organic molecule
Emp. Form.:
C22H25F3N4O
Mol. Mass.:
418.4553
SMILES:
CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C(F)(F)F)n2n1 |r,wU:7.10,wD:4.3,(-8.7,2.48,;-7.36,3.25,;-7.36,4.79,;-8.7,4.02,;-6.03,2.48,;-6.03,.94,;-4.7,.17,;-3.36,.94,;-3.36,2.48,;-4.7,3.25,;-2.03,.17,;-.69,.94,;-.69,2.48,;.64,3.25,;1.97,2.48,;3.44,2.96,;4.34,1.71,;3.44,.47,;3.84,-1.02,;2.75,-2.11,;3.15,-3.6,;4.63,-4,;5.82,-2.9,;5.32,-1.42,;7.31,-3.28,;8.8,-3.66,;6.93,-4.77,;7.69,-1.79,;1.97,.94,;.64,.17,)|
Structure:
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