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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242398
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
52±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242398
Synonyms:
US10047093, 8-80 | US10392392, Example 8-80 | US10875864, EX. 8-80 | US9416132, 8-80
Type:
Small organic molecule
Emp. Form.:
C19H22ClN5O2S
Mol. Mass.:
419.928
SMILES:
CS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(Cl)c3)n2n1 |r,wU:5.4,wD:8.11,(-8.62,2.08,;-7.29,2.85,;-8.62,3.62,;-7.29,1.31,;-5.95,3.62,;-4.62,2.85,;-3.29,3.62,;-1.95,2.85,;-1.95,1.31,;-3.29,.54,;-4.62,1.31,;-.62,.54,;.72,1.31,;.72,2.85,;2.05,3.62,;3.38,2.85,;4.85,3.33,;5.75,2.08,;4.85,.84,;5.25,-.65,;4.16,-1.74,;4.56,-3.23,;6.04,-3.62,;7.13,-2.54,;8.62,-2.93,;6.73,-1.05,;3.38,1.31,;2.05,.54,)|
Structure:
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