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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242402
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
19±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242402
Synonyms:
US10392392, Example 8-85 | US10875864, EX. 8-85 | US9416132, 8-85
Type:
Small organic molecule
Emp. Form.:
C20H18F3N5
Mol. Mass.:
385.3856
SMILES:
FC(F)(F)c1cccc(c1)-c1cnc2ccc(N[C@H]3CC[C@@H](CC3)C#N)nn12 |r,wU:21.25,wD:18.18,(8.75,-3.33,;7.26,-2.93,;7.66,-1.45,;6.86,-4.42,;5.78,-2.54,;4.63,-3.61,;3.15,-3.21,;2.75,-1.72,;3.84,-.64,;5.32,-1.03,;3.44,.85,;4.34,2.1,;3.44,3.34,;1.97,2.87,;.64,3.64,;-.69,2.87,;-.69,1.33,;-2.03,.56,;-3.36,1.33,;-3.36,2.87,;-4.7,3.64,;-6.12,2.88,;-6.03,1.33,;-4.7,.56,;-7.47,3.64,;-8.81,4.4,;.64,.56,;1.97,1.33,)|
Structure:
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