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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242354
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
9±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242354
Synonyms:
US10047093, 8-10 | US10392392, Example 8-10 | US10875864, EX. 8-10 | US9416132, 8-10
Type:
Small organic molecule
Emp. Form.:
C22H25F3N4O2
Mol. Mass.:
434.4547
SMILES:
CC(C)(O)[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1 |r,wU:7.10,wD:4.3,(-9.24,2.08,;-7.91,2.85,;-7.91,4.39,;-9.24,3.62,;-6.57,2.08,;-6.57,.54,;-5.24,-.23,;-3.91,.54,;-3.91,2.08,;-5.24,2.85,;-2.57,-.23,;-1.24,.54,;-1.24,2.08,;.09,2.85,;1.43,2.08,;2.89,2.56,;3.8,1.31,;2.89,.07,;3.29,-1.42,;2.2,-2.51,;2.6,-4,;4.09,-4.39,;5.23,-3.32,;6.72,-3.72,;7.81,-2.63,;8.9,-1.54,;8.9,-3.72,;6.72,-1.54,;4.78,-1.82,;1.43,.54,;.09,-.23,)|
Structure:
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