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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM242369
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
28±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM242369
Synonyms:
US10047093, 8-26 | US10392392, Example 8-26 | US9416132, 8-26
Type:
Small organic molecule
Emp. Form.:
C19H19N5O
Mol. Mass.:
333.3871
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(c3)C#N)n2n1 |r,wU:1.0,wD:4.7,(-8.03,3.62,;-6.7,2.85,;-5.36,3.62,;-4.03,2.85,;-4.03,1.31,;-5.36,.54,;-6.7,1.31,;-2.7,.54,;-1.36,1.31,;-1.36,2.85,;-.03,3.62,;1.31,2.85,;2.77,3.33,;3.68,2.08,;2.77,.84,;3.17,-.65,;2.08,-1.74,;2.48,-3.23,;3.97,-3.62,;5.15,-2.53,;4.66,-1.05,;6.64,-2.91,;8.14,-3.29,;1.31,1.31,;-.03,.54,)|
Structure:
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