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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043690
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
27±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043690
Synonyms:
CHEMBL3355544 | US10047093, 8-46 | US10392392, Example 8-46 | US10875864, EX. 8-46 | US9416132, 8-46
Type:
Small organic molecule
Emp. Form.:
C19H19F3N4O2
Mol. Mass.:
392.375
SMILES:
O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(50.22,-3.1,;51.55,-3.88,;52.88,-3.11,;54.21,-3.88,;54.21,-5.42,;52.88,-6.19,;51.55,-5.42,;55.54,-6.19,;56.88,-5.42,;56.88,-3.88,;58.21,-3.1,;59.54,-3.88,;61,-3.4,;61.91,-4.65,;61,-5.9,;61.76,-7.23,;60.97,-8.56,;61.73,-9.9,;63.27,-9.91,;64.05,-8.58,;65.59,-8.59,;66.35,-9.93,;67.89,-9.94,;65.57,-11.25,;67.03,-11.3,;63.29,-7.24,;59.54,-5.42,;58.21,-6.18,)|
Structure:
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