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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50043692
Substrate
n/a
Meas. Tech.
Kinase-Glo Assay
Temperature
298.15±n/a K
IC50
5±n/a nM
Comments
extracted
Citation
 Xu, Y; Brenning, BG; Kultgen, SG; Liu, X; Saunders, M; Ho, K Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors US Patent  US9416132 Publication Date 8/16/2016 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50043692
Synonyms:
CHEMBL3355542 | US10047093, 8-52 | US10392392, Example 8-52 | US10875864, EX. 8-52 | US9416132, 8-52
Type:
Small organic molecule
Emp. Form.:
C19H20F3N5O
Mol. Mass.:
391.3902
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(OC(F)(F)F)c3)c2n1 |r,wU:1.0,wD:4.7,(16.04,-2.27,;17.37,-3.04,;18.71,-2.28,;20.04,-3.05,;20.04,-4.59,;18.71,-5.36,;17.37,-4.59,;21.37,-5.36,;22.7,-4.59,;22.7,-3.05,;24.03,-2.27,;25.36,-3.05,;26.83,-2.57,;27.73,-3.82,;26.83,-5.07,;27.58,-6.4,;26.8,-7.73,;27.55,-9.07,;29.09,-9.08,;29.88,-7.75,;31.42,-7.76,;32.18,-9.09,;33.72,-9.1,;31.4,-10.42,;32.86,-10.47,;29.12,-6.41,;25.36,-4.59,;24.03,-5.35,)|
Structure:
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